Active, Not Recruiting

Transcranial Electrical Stimulation for Mal de Debarquement Syndrome

The goal of this study is to determine whether external neuromodulation using transcranial electrical stimulation (TES) can reduce the perception of self-motion that is experienced by patients with MdDS. Mal de debarquement is translated as the “sickness of disembarkment,” and refers to the chronic feeling of rocking dizziness that occurs after exposure to passive motion. A similar form of rocking dizziness can be experienced without a motion trigger in individuals with certain risk factors.

Treatment for MdDS is limited and morbidity is high. The goal of the study is to determine whether TES can suppress the rocking dizziness of MdDS either as a standalone therapy or as an adjunctive therapy to other forms of neuromodulation such as transcranial magnetic stimulation. The investigators will determine the optimal treatment duration and stimulation parameters.

Location: University of Minnesota, Minneapolis, Minnesota, United States
Sponsors & Collaborators: University of Minnesota
Investigators: Principal Investigator: Yoon-Hee Cha University of Minnesota

ClinicalTrials.gov identifier (NCT number): NCT02540616

Recruiting

Treatments of Mal de Debarquement Syndrome (MdDS) by Habituation of Velocity Storage

Mal de Debarquement Syndrome (MdDS) is an under-recognized but nevertheless common balance disorder, which in most cases occurs after exposure to prolonged passive motion. The current treatment approaches focus on reducing symptoms, but they can be retriggered. This project aims to shift the focus of MdDS treatment to permanently eliminating the symptom trigger while also minimizing symptoms.

Location: Vestibular Testing Center, New York, New York, United States
Sponsors & Collaborators: Icahn School of Medicine at Mount Sinai & National Institute on Deafness and Other Communication Disorders (NIDCD)
Investigators: Principal Investigator: Sergei Yakushin, PhD, Icahn School of Medicine at Mount Sinai

ClinicalTrials.gov identifier (NCT number): NCT04213079

Not Yet Recruiting

WAVES for Mal de Debarquement Syndrome

This study will be recruiting individuals with Mal de Debarquement Syndrome (MdDS), a disorder caused by entrainment to oscillating motion that leads to persistent oscillating vertigo. The typical triggers for MdDS are sea and air travel. Prior studies on MdDS have shown that functional connectivity measured by both EEG and fMRI decreases when symptoms of MdDS improve. This study seeks to use asynchronous visual and auditory stimulation provided through a smart-phone app (WAVES) administered through virtual reality goggles to modulate the vertigo in MdDS with the hypothesis that these stimuli can desynchronize functional connectivity.

Location: _
Sponsor: University of Minnesota
Information provided by (Responsible Party): University of Minnesota

Completed

Transcranial Magnetic Stimulation for Mal de Debarquement Syndrome

The goal of this study is to determine whether external neuromodulation using repetitive transcranial magnetic stimulation (rTMS) can reduce the perception of self-motion that is experienced by individuals with mal de debarquement syndrome (MdDS). Mal de debarquement is translated as the “sickness of disembarkment,” and refers to the chronic feeling of rocking dizziness that occurs after exposure to passive motion. Treatment for MdDS is limited and morbidity is high. The goal of the study is to determine whether rTMS can suppress the rocking dizziness of MdDS and to determine whether imaging and electrical biomarkers can aide in more effective targeting. The investigators will make correlations between functional magnetic resonance imaging (fMRI), electroencephalography (EEG), and specific clinical features to determine whether functional connectivity between particular hubs in the brain correlate with clinical improvement.

Location: University of Minnesota, Minneapolis, Minnesota, United States
Sponsors & Collaborators: University of Minnesota
Investigators: Principal Investigator: Yoon-Hee Cha University of Minnesota

Comprehensive information on MdDS clinical studies can be found on ClinicalTrials.gov.

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