Transcranial Magnetic Stimulation for Mal de Debarquement Syndrome

The goal of this study is to determine whether external neuromodulation using repetitive transcranial magnetic stimulation (rTMS) can reduce the perception of self-motion that is experienced by individuals with mal de debarquement syndrome (MdDS). Mal de debarquement is translated as the “sickness of disembarkment,” and refers to the chronic feeling of rocking dizziness that occurs after exposure to passive motion. Treatment for MdDS is limited and morbidity is high. The goal of the study is to determine whether rTMS can suppress the rocking dizziness of MdDS and to determine whether imaging and electrical biomarkers can aide in more effective targeting. The investigators will make correlations between functional magnetic resonance imaging (fMRI), electroencephalography (EEG), and specific clinical features to determine whether functional connectivity between particular hubs in the brain correlate with clinical improvement.

Location: University of Minnesota, Minneapolis, Minnesota, United States
Sponsors & Collaborators: University of Minnesota
Investigators: Principal Investigator: Yoon-Hee Cha University of Minnesota

Results First Posted : August 31, 2022

Not Yet Completed

Comprehensive information on MdDS clinical studies, some funded by the MdDS Foundation, can be found on the National Institutes of Health (NIH) US National Library of Medicine website. The NIH site shows all statuses including those that are active/not recruiting, not yet recruiting, and recruiting.

Studies that are not recruiting may be awaiting Institutional Review Board (IRB) approval. An IRB, also known as an independent ethics committee, ethical review board, or research ethics board, is a type of committee that applies research ethics by reviewing the methods proposed for research to ensure that they are ethical. NIH protocols, to which the MdDS Foundation adhere, require each investigator (researcher) to have an IRB established for their work. An IRB ensures patient safety.

Research Results

Study Details, Study Results, and Publications of Results may be found through the NIH website.

MdDS Biomedical Literature
Biomedical research findings are published in peer-reviewed medical and healthcare journals to advance the practice and delivery of patient care. To be impactful, publications must represent research that is completed in a well-designed and reproducible manner despite the fact that rigorous clinical research studies are expensive as well as labor- and time-intensive. This follows the global standard for biomedical research which provides a level of safety for patients.

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