Yoon-Hee Cha, MD – MdDS Research

8.19.2022

Update on therapies for Mal de Débarquement Syndrome

Abstract Purpose of Review This review will discuss current treatment options for mal de débarquement syndrome (MdDS) and non-motion triggered persistent oscillating vertigo (nmPOV). Therapies available in most clinical settings such as modifying homeostatic factors (sleep, stress, menstrual cycle, visual stimulation), medications (benzodiazepines, serotonin reuptake inhibitors), and vestibular/physical therapy are discussed. Travel precautions should incorporate […]

4.1.2022

Psychological assessment of individuals with Mal de Débarquement Syndrome

Abstract Objective: To report on the psychological, personality, and behavioral profiles of individuals with persistent Mal de Débarquement Syndrome (MdDS). Materials and methods: Individuals with MdDS who participated in neuromodulation clinical trials between May 2013 and June 2019 completed a series of standardized psychological questionnaires and underwent the Structural Clinical Interview for DSM-IV-TR (SCID) for […]

2.4.2022

Double-blind randomized N-of-1 trial of transcranial alternating current stimulation for mal de débarquement syndrome

Abstract Background: Mal de Débarquement Syndrome (MdDS) is a medically refractory neurotological disorder characterized by persistent oscillating vertigo that follows a period of entrainment to oscillating motion such as experienced during sea or air travel. Fronto-occipital hypersynchrony may correlate with MdDS symptom severity. Materials and methods: Individuals with treatment refractory MdDS lasting at least 6 […]

12.9.2021

Remotely Monitored Home-Based Neuromodulation With Transcranial Alternating Current Stimulation (tACS) for Mal de Débarquement Syndrome

Abstract Objective: To determine whether remotely-monitored transcranial alternating current stimulation (tACS) may be a viable and safe treatment option for Mal de Débarquement Syndrome (MdDS). Background: Mal de Débarquement Syndrome is a neurotological disorder characterized by persistent oscillating vertigo that is triggered by entrainment to passive oscillatory motion such as occurs during water-based travel. Treatment […]

11.30.2021

Brain network effects by continuous theta burst stimulation in mal de débarquement syndrome: simultaneous EEG and fMRI study

Abstract Objective. Heterogeneous clinical responses to treatment with non-invasive brain stimulation are commonly observed, making it necessary to determine personally optimized stimulation parameters. We investigated neuroimaging markers of effective brain targets of treatment with continuous theta burst stimulation (cTBS) in mal de débarquement syndrome (MdDS), a balance disorder of persistent oscillating vertigo previously shown to […]

4.20.2021

fMRI and transcranial electrical stimulation (tES): A systematic review of parameter space and outcomes

Abstract The combination of non-invasive brain stimulation interventions with human brain mapping methods have supported research beyond correlational associations between brain activity and behavior. Functional MRI (fMRI) partnered with transcranial electrical stimulation (tES) methods, i.e., transcranial direct current (tDCS), transcranial alternating current (tACS), and transcranial random noise (tRNS) stimulation, explore the neuromodulatory effects of tES […]

4.13.2021

Remotely monitored home-based transcranial alternating current stimulation for mal de debarquement syndrome

Abstract Objective: To determine whether remotely monitored at-home Transcranial Alternating Current Stimulation (tACS) may be an effective and safe treatment option for Mal de Débarquement Syndrome (MdDS). Background: Treatment options for MdDS are limited, costly, and difficult to access. This study explored the viability of an at-home, self-administered tACS program for treatment of MdDS. The […]

4.1.2021

Chronic dizziness

Abstract Purpose of review: Determining the etiology of disorders that manifest with chronic dizziness can seem a daunting task, but extracting some basic elements of the patient’s history can reduce the differential diagnosis significantly. This includes determining initial triggers, timing of symptoms, associated features, and exacerbating factors. This article covers distinct causes of chronic dizziness […]