Is there a connection between MdDS and hormones? It is common for individuals with various chronic conditions to notice a temporary increase in baseline symptoms during hormonal fluctuations, such as the menstrual cycle. However, a temporary increase in symptoms does not mean hormones cause the disorder.While MdDS is more frequently diagnosed in women, a definitive link to hormones has not been established. The biological factors involved in the development, exacerbation, or remission of MdDS are not fully understood. The MdDS Patient Registry (coming in 2026) aims to collect data that will help researchers better evaluate any patterns based on clinical evidence rather than speculation.